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Open Access Review

Potential application of hydrogen in traumatic and surgical brain injury, stroke and neonatal hypoxia-ischemia

Jan M Eckermann15*, Paul R Krafft3, Lorelei Shoemaker1, Robert E Lieberson1, Steven D Chang12 and Austin Colohan4*

Author Affiliations

1 Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA

2 Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA

3 Department of Physiology, Loma Linda University School of Medicine, Loma Linda, California, USA

4 Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, California, USA

5 Department of Neurosurgery, Stanford Hospital and Clinics, 300 Pasteur Drive, Room R281, Stanford, CA 94304, USA

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Medical Gas Research 2012, 2:11  doi:10.1186/2045-9912-2-11

Published: 19 April 2012

Abstract

This article summarized findings of current preclinical studies that implemented hydrogen administration, either in the gas or liquid form, as treatment application for neurological disorders including traumatic brain injury (TBI), surgically induced brain injury (SBI), stroke, and neonatal hypoxic-ischemic brain insult (HI). Most reviewed studies demonstrated neuroprotective effects of hydrogen administration. Even though anti-oxidative potentials have been reported in several studies, further neuroprotective mechanisms of hydrogen therapy remain to be elucidated. Hydrogen may serve as an adjunct treatment for neurological disorders.

Keywords:
Hydrogen; Neuroprotection; Oxidative stress; Reactive oxygen species