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Open Access Highly Accessed Research

Hydrogen is neuroprotective against surgically induced brain injury

Jan M Eckermann1, Wanqiu Chen2, Vikram Jadhav2, Frank PK Hsu1, Austin RT Colohan1, Jiping Tang2 and John H Zhang123*

Author Affiliations

1 Department of Neurosurgery, Loma Linda University Medical Center, 11234 Anderson Street, Loma Linda, CA 92354, USA

2 Department of Physiology and Pharmacology, Loma Linda University Medical Center, 11234 Anderson Street, Loma Linda, CA 92354, USA

3 Department of Anesthesiology, Loma Linda University Medical Center, 11234 Anderson Street, Loma Linda, CA 92354, USA

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Medical Gas Research 2011, 1:7  doi:10.1186/2045-9912-1-7

Published: 18 May 2011

Abstract

Background

Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in an established surgical brain injury (SBI) model in rats.

Materials and methods

Adult male Sprague - Dawley rats (weight 300-350g) were divided into three groups to serve as sham operated, SBI without treatment, and SBI treated with H2 (2.9%). Brain water content, myeloperoxidase (MPO) assay, lipid peroxidation (LPO), and neurological function were measured at 24 hrs after SBI.

Results

SBI resulted in localized brain edema (p = < 0.001). Hydrogen (2.9%) administered concurrently with surgery significantly decreased the formation of cerebral edema (p = 0.028) and improved neurobehavioral score (p = 0.022). However, hydrogen treatment failed to reduce oxidative stress (LPO assay) or inflammation (MPO assay) in brain tissues.

Conclusions

Hydrogen appears to be promising as an effective, yet inexpensive way to reduce cerebral edema caused by surgical procedures. Hydrogen has the potential to improve clinical outcome, decrease hospital stay, and reduce overall cost to patients and the health care system.