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1.

580
Accesses

Research   Open Access

Hyperbaric oxygen preconditioning attenuates hyperglycemia enhanced hemorrhagic transformation after transient MCAO in rats

Yoshiteru Soejima, Robert P Ostrowski, Anatol Manaenko, Mutsumi Fujii, Jiping Tang, John H Zhang Medical Gas Research 2012, 2:9 (11 April 2012)

Abstract | Full text | PDF | PubMed

2.

557
Accesses

Review   Open Access Highly Accessed

Hyperbaric oxygen therapy for traumatic brain injury

Lei Huang, Andre Obenaus Medical Gas Research 2011, 1:21 (6 September 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

512
Accesses

Review   Open Access

Hydrogen sulfide as a vasculoprotective factor

Eloise Streeter, Hooi H Ng, Joanne L Hart Medical Gas Research 2013, 3:9 (29 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

4.

506
Accesses

Short communication   Open Access Highly Accessed

Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors

Ki-Mun Kang, Young-Nam Kang, Ihil-Bong Choi, Yeunhwa Gu, Tomohiro Kawamura, Yoshiya Toyoda, Atsunori Nakao Medical Gas Research 2011, 1:11 (7 June 2011)

Abstract | Full text | PDF

5.

478
Accesses

Review   Open Access Highly Accessed

Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?

Masaru Sagai, Velio Bocci Medical Gas Research 2011, 1:29 (20 December 2011)

Abstract | Full text | PDF | PubMed

6.

411
Accesses

Review   Open Access Highly Accessed

Hyperbaric oxygen treatment in autism spectrum disorders

Daniel A Rossignol, James J Bradstreet, Kyle Van Dyke, Cindy Schneider, Stuart H Freedenfeld, Nancy O’Hara, Stephanie Cave, Julie A Buckley, Elizabeth A Mumper, Richard E Frye Medical Gas Research 2012, 2:16 (15 June 2012)

Abstract | Full text | PDF | ePUB | PubMed

7.

407
Accesses

Review   Open Access

XENON in medical area: emphasis on neuroprotection in hypoxia and anesthesia

Ecem Esencan, Simge Yuksel, Yusuf Berk Tosun, Alexander Robinot, Ihsan Solaroglu, John H Zhang Medical Gas Research 2013, 3:4 (1 February 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

328
Accesses

Research   Open Access

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells

Akio Iio, Mikako Ito, Tomohiro Itoh, Riyako Terazawa, Yasunori Fujita, Yoshinori Nozawa, Ikuroh Ohsawa, Kinji Ohno, Masafumi Ito Medical Gas Research 2013, 3:6 (1 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

9.

321
Accesses

Commentary   Open Access

The summer of hydrogen sulfide: highlights from two international conferences

John W Calvert Medical Gas Research 2013, 3:5 (25 February 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

306
Accesses

Review   Open Access Highly Accessed

Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis

Daniel A Rossignol Medical Gas Research 2012, 2:6 (15 March 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

11.

289
Accesses

Commentary   Open Access

Are volatile anesthetics neuroprotective or neurotoxic?

Zhiyi Zuo Medical Gas Research 2012, 2:10 (17 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

12.

269
Accesses

Review   Open Access Highly Accessed

Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects

Velio Bocci, Iacopo Zanardi, Valter Travagli Medical Gas Research 2011, 1:6 (28 April 2011)

Abstract | Full text | PDF

13.

264
Accesses

Case report   Open Access Highly Accessed

Hyperbaric oxygen therapy (1.5 ATA) in treating sports related TBI/CTE: two case reports

Kenneth P Stoller Medical Gas Research 2011, 1:17 (5 July 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

14.

265
Accesses

Research   Open Access Highly Accessed

Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes

Kosuke Aoki, Atsunori Nakao, Takako Adachi, Yasushi Matsui, Shumpei Miyakawa Medical Gas Research 2012, 2:12 (20 April 2012)

Abstract | Full text | PDF | PubMed

15.

256
Accesses

Study protocol   Open Access

A convenient method for determining the concentration of hydrogen in water: use of methylene blue with colloidal platinum

Tomoki Seo, Ryosuke Kurokawa, Bunpei Sato Medical Gas Research 2012, 2:1 (24 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

16.

250
Accesses

Review   Open Access

The immunomodulatory role of carbon monoxide during transplantation

Mariane Amano, Niels Olsen Saraiva Camara Medical Gas Research 2013, 3:1 (7 January 2013)

Abstract | Full text | PDF | ePUB | PubMed | Cited on BioMed Central

17.

234
Accesses

Review   Open Access Highly Accessed

Hyperbaric oxygen therapy for treatment of children with autism: a systematic review of randomized trials

Ahmad Ghanizadeh Medical Gas Research 2012, 2:13 (11 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

233
Accesses

Research   Open Access Highly Accessed

Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study

Toru Ishibashi, Bunpei Sato, Mariko Rikitake, Tomoki Seo, Ryosuke Kurokawa, Yuichi Hara, Yuji Naritomi, Hiroshi Hara, Tetsuhiko Nagao Medical Gas Research 2012, 2:27 (2 October 2012)

Abstract | Full text | PDF | ePUB | PubMed

19.

232
Accesses

Review   Open Access

Xenon preconditioning: molecular mechanisms and biological effects

Wenwu Liu, Ying Liu, Han Chen, Kan Liu, Hengyi Tao, Xuejun Sun Medical Gas Research 2013, 3:3 (10 January 2013)

Abstract | Full text | PDF | ePUB | PubMed

20.

225
Accesses

Commentary   Open Access Highly Accessed

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?

Jun Mu, Paul R Krafft, John H Zhang Medical Gas Research 2011, 1:14 (27 June 2011)

Abstract | Full text | PDF | PubMed

21.

228
Accesses

Review   Open Access

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance

Brandon J Dixon, Jiping Tang, John H Zhang Medical Gas Research 2013, 3:10 (16 May 2013)

Abstract | Full text | PDF | PubMed

22.

217
Accesses

Review   Open Access Highly Accessed

Application of medical gases in the field of neurobiology

Wenwu Liu, Nikan Khatibi, Aishwarya Sridharan, John H Zhang Medical Gas Research 2011, 1:13 (27 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

23.

211
Accesses

Research   Open Access

Serum leptin levels decrease after permanent MCAo in the rat and remain unaffected by delayed hyperbaric oxygen therapy

Jun Mu, Robert P Ostrowski, Paul R Krafft, Jiping Tang, John H Zhang Medical Gas Research 2013, 3:8 (19 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

24.

205
Accesses

Commentary   Open Access Highly Accessed

The 2011 Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal Medical Gas Research

Shigeo Ohta, Atsunori Nakao, Kinji Ohno Medical Gas Research 2011, 1:10 (7 June 2011)

Abstract | Full text | PDF

25.

194
Accesses

Review   Open Access

Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke

Zhifeng Qi, Wenlan Liu, Yumin Luo, Xunming Ji, Ke Jian Liu Medical Gas Research 2013, 3:2 (9 January 2013)

Abstract | Full text | PDF | ePUB | PubMed

26.

191
Accesses

Letter to the Editor   Open Access

A hypothesis on chemical mechanism of the effect of hydrogen

Penghui Shi, Wancang Sun, Pengzhong Shi Medical Gas Research 2012, 2:17 (21 June 2012)

Abstract | Full text | PDF | ePUB | PubMed | Cited on BioMed Central

27.

188
Accesses

Research   Open Access

Methods for evaluation of helium/oxygen delivery through non-rebreather facemasks

Andrew R Martin, Ira M Katz, Yonatan Lipsitz, Karine Terzibachi, Georges Caillibotte, Joëlle Texereau Medical Gas Research 2012, 2:31 (17 December 2012)

Abstract | Full text | PDF | ePUB | PubMed

28.

188
Accesses

Review   Open Access

Emerging concepts on the anti-inflammatory actions of carbon monoxide-releasing molecules (CO-RMs)

Roberto Motterlini, Benjamin Haas, Roberta Foresti Medical Gas Research 2012, 2:28 (21 November 2012)

Abstract | Full text | PDF | ePUB | PubMed | Cited on BioMed Central

29.

186
Accesses

Review   Open Access

The role of Volatile Anesthetics in Cardioprotection: a systematic review

Nicole R Van Allen, Paul R Krafft, Arthur S Leitzke, Richard L Applegate, Jiping Tang, John H Zhang Medical Gas Research 2012, 2:22 (28 August 2012)

Abstract | Full text | PDF | ePUB | PubMed

30.

177
Accesses

Review   Open Access

Emergent role of gasotransmitters in ischemia-reperfusion injury

Bridgette F Moody, John W Calvert Medical Gas Research 2011, 1:3 (27 April 2011)

Abstract | Full text | PDF

31.

168
Accesses

Case report   Open Access Highly Accessed

Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study

Hirohisa Ono, Yoji Nishijima, Naoto Adachi, Shigekuni Tachibana, Shiroh Chitoku, Shigeo Mukaihara, Masaki Sakamoto, Yohei Kudo, Jun Nakazawa, Kumi Kaneko, Hiroshi Nawashiro Medical Gas Research 2011, 1:12 (7 June 2011)

Abstract | Full text | PDF

32.

170
Accesses

Research   Open Access

Inhaled hydrogen sulfide protects against lipopolysaccharide-induced acute lung injury in mice

Simone Faller, Kornelia K Zimmermann, Karl M Strosing, Helen Engelstaedter, Hartmut Buerkle, René Schmidt, Sashko G Spassov, Alexander Hoetzel Medical Gas Research 2012, 2:26 (1 October 2012)

Abstract | Full text | PDF | ePUB | PubMed

33.

159
Accesses

Editorial   Open Access

Quoth the Raven: carbon monoxide and nothing more

Leo E Otterbein Medical Gas Research 2013, 3:7 (6 March 2013)

Abstract | Full text | PDF | ePUB | PubMed

34.

155
Accesses

Case report   Open Access

A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level

Hirohisa Ono, Yoji Nishijima, Naoto Adachi, Masaki Sakamoto, Yohei Kudo, Kumi Kaneko, Atsunori Nakao, Takashi Imaoka Medical Gas Research 2012, 2:21 (23 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

35.

155
Accesses

Research   Open Access

Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore

Yiying Zhang, Yuanlin Dong, Zhipeng Xu, Zhongcong Xie Medical Gas Research 2012, 2:20 (17 August 2012)

Abstract | Full text | PDF | ePUB | PubMed

36.

154
Accesses

Research   Open Access

Oxybiotest project: microorganisms under pressure. Hyperbaric oxygen (HBO) and simple pressure interaction on selected bacteria

Vincenzo Zanon, Lucia Rossi, Elena Castellani, Enrico Camporesi, Giorgio Palù, Gerardo Bosco Medical Gas Research 2012, 2:24 (11 September 2012)

Abstract | Full text | PDF | ePUB | PubMed

37.

154
Accesses

Review   Open Access

Effect of carbon monoxide on Mycobacterium tuberculosis pathogenesis

Vineetha M Zacharia, Michael U Shiloh Medical Gas Research 2012, 2:30 (17 December 2012)

Abstract | Full text | PDF | ePUB | PubMed | Cited on BioMed Central

38.

153
Accesses

Review   Open Access

Potential application of hydrogen in traumatic and surgical brain injury, stroke and neonatal hypoxia-ischemia

Jan M Eckermann, Paul R Krafft, Lorelei Shoemaker, Robert E Lieberson, Steven D Chang, Austin Colohan Medical Gas Research 2012, 2:11 (19 April 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

39.

150
Accesses

Research   Open Access Highly Accessed

Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies

Mikako Ito, Tohru Ibi, Ko Sahashi, Masashi Ichihara, Masafumi Ito, Kinji Ohno Medical Gas Research 2011, 1:24 (3 October 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

40.

147
Accesses

Research   Open Access

Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney

Masanori Katakura, Michio Hashimoto, Yoko Tanabe, Osamu Shido Medical Gas Research 2012, 2:18 (9 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

41.

146
Accesses

Letter to the Editor   Open Access

Physical exercise and intermittent administration of lactulose may improve autism symptoms through hydrogen production

Ahmad Ghanizadeh Medical Gas Research 2012, 2:19 (30 July 2012)

Abstract | Full text | PDF | ePUB | PubMed

42.

146
Accesses

Commentary   Open Access

Is methane a new therapeutic gas?

Wenwu Liu, Dong Wang, Hengyi Tao, XueJun Sun Medical Gas Research 2012, 2:25 (25 September 2012)

Abstract | Full text | PDF | ePUB | PubMed

43.

148
Accesses

Letter to the Editor   Open Access

Lactulose: an effective preventive and therapeutic option for ischemic stroke by production of hydrogen

Xiao Chen, Xiao Zhai, Zhimin Kang, Xuejun Sun Medical Gas Research 2012, 2:3 (6 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

44.

146
Accesses

Review   Open Access

Neuroprotective, neurotherapeutic, and neurometabolic effects of carbon monoxide

Vicki L Mahan Medical Gas Research 2012, 2:32 (27 December 2012)

Abstract | Full text | PDF | ePUB | PubMed | Cited on BioMed Central

45.

146
Accesses

Research   Open Access

ACS6, a Hydrogen sulfide-donating derivative of sildenafil, inhibits homocysteine-induced apoptosis by preservation of mitochondrial function

Xiao-Qing Tang, Rong-Qian Chen, Yan-Kai Ren, Piero Soldato, Anna Sparatore, Yuan-Yuan Zhuang, Hen-Rong Fang, Chun-Yan Wang Medical Gas Research 2011, 1:20 (16 August 2011)

Abstract | Full text | PDF | PubMed

46.

144
Accesses

Review   Open Access

A hypothesis on biological protection from space radiation through the use of new therapeutic gases as medical counter measures

Michael P Schoenfeld, Rafat R Ansari, Atsunori Nakao, David Wink Medical Gas Research 2012, 2:8 (4 April 2012)

Abstract | Full text | PDF | PubMed

47.

136
Accesses

Research   Open Access

Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats

Mikako Ito, Masaaki Hirayama, Kazuaki Yamai, Sae Goto, Masafumi Ito, Masatoshi Ichihara, Kinji Ohno Medical Gas Research 2012, 2:15 (20 May 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

48.

134
Accesses

Research   Open Access

Colonic insufflation with carbon monoxide gas inhibits the development of intestinal inflammation in rats

Tomohisa Takagi, Yuji Naito, Kazuhiko Uchiyama, Toshimitsu Okuda, Takahiro Suzuki, Hisato Tsuboi, Katsura Mizushima, Osamu Handa, Nobuaki Yagi, Hiroshi Ichikawa, Toshikazu Yoshikawa Medical Gas Research 2012, 2:23 (3 September 2012)

Abstract | Full text | PDF | ePUB | PubMed | Cited on BioMed Central

49.

127
Accesses

Research   Open Access Highly Accessed

Hydrogen is neuroprotective against surgically induced brain injury

Jan M Eckermann, Wanqiu Chen, Vikram Jadhav, Frank PK Hsu, Austin RT Colohan, Jiping Tang, John H Zhang Medical Gas Research 2011, 1:7 (18 May 2011)

Abstract | Full text | PDF |  Editor’s summary

Inhaled hydrogen could be used as an effective, and inexpensive treatment to reduce neurosurgery induced brain edema and tissue injury, as displayed in adult male Sprague–Dawley rats.

50.

127
Accesses

Short communication   Open Access

Interrelations between blood-brain barrier permeability and matrix metalloproteinases are differently affected by tissue plasminogen activator and hyperoxia in a rat model of embolic stroke

Dominik Michalski, Carsten Hobohm, Christopher Weise, Johann Pelz, Marita Heindl, Manja Kamprad, Johannes Kacza, Wolfgang Härtig Medical Gas Research 2012, 2:2 (24 January 2012)

Abstract | Full text | PDF | PubMed

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